Apoptosis and p53 status of the upper urothelial carcinomas from Balkan endemic nephropathy regions

Apoptosis and p53 status of the upper urothelial carcinomas from Balkan endemic nephropathy regions.

The upper urothelial carcinomas (UUC) associated with endemic nephropathy and analgesic nephropathy are considerably similar in many characteristics. These similarities diversify them from the same carcinomas in the general population w1x. Bilateral occurrence (simultaneous or successive) of the UUC is observed in about 8% cases of analgesic nephropathy and 10–14% in endemic Balkan nephropathy....

Upper Urothelial Carcinomas Associated with Balkan Endemic Nephropathy and Their Similarities with Upper Urothelial Carcinomas in Analgesic Nephropathy

The incidence of upper urothelial carcinomas (UUC) is even more than hundred times higher in the foci of Balkan endemic nephropathy (BEN), by investigations of our team, and others. Every tenth patient suffers from both diseases. Etiology is unknown. It would seem that BEN is a tubulointerstitial nephritis associated with urothelial malignancy. We found that apoptosis plays an important role in...

Current Research in Balkan Endemic Nephropathy and Associated Urothelial Cancer

Pro- and Antiapoptotic Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper-tract urothelial carcinoma (UTUC) has been recently confirmed. The aim of this study was to determine apoptosis-related marker(s) specific for BEN-associated UTUC. Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors. Altered expression of Survivin wa...

Balkan Endemic Nephropathy and Associated Urothelial Cancer: Current Status and Future Research

_______________________________ Correspondence to: Goce B Spasovski, MD, PhD, Department of Nephrology, Clinical Center Skopje, Vodnjanska 17, 1000 Skopje, Macedonia, Fax: +389 2 3220 935 or +389 2 3231 501, E-mail: [email protected] Balkan Endemic Nephropathy and Associated Urothelial Cancer: Current Status and Future Research V. Stefanovic Institute of Nephrology and Hemodialysis, Faculty of...